IPHARMA provides full cycle of clinical development from early phase trials to registration and post-marketing PV.

Services

IPHARMA conducts pre-clinical studies, develops and manufactures FDFs on the basis of a ChemRar hi-tech laboratory. Having a 25-year experience in the international drug development market, ChemRar  conducts pre-clinical studies in compliance with all international requirements and guidelines.

​

Types of research

​

1. High Throughput Screening 

• Ion channels, GPCR, kinases, HDACs, viral polymerase and protease, etc.

​

2. In vitro metabolism

• Stability (microsomes and hepatocytes of mouses, rats, dogs, monkeys and humans)

• Permeability (PAMPA test, Caco-2 cell line)

• Solubility, lipophilicity, plasma protein binding

• Interaction with the human cytochrome P450

​

3. In vivo metabolism

• Pharmacokinetics (LC / MS / MS high sensitivity)

• Bioavailability, biodistribution

• Study of Bioavailability and Bioequivalence

 

4. Pharmacology. Study of the pharmacological activity

• CNS model, Parkinsonism

• Obesity, violation of food and water consumption, type I diabetes

• Anti-inflammatory and analgesic activity

• Xenografts of human tumors

• Antiviral activity (hepatitis C, influenza)

• ​

5. Toxicology. The study of acute and chronic toxicity

• Study of the general toxicity of substances (acute, sub-chronic, chronic)

• Specific (allergenicity, immunotoxicity, reproductive toxicity)

• Various species (SPF and non-SPF mice, rats, rabbits, minipigi)

​

Organization of pre-clinical studies

​

• Clinical laboratory selection

• Development of the protocol and other study documents

• Safety monitoring

• Quality assurance

• Reports preparation