IPHARMA provides full cycle of clinical development from early phase trials to registration and post-marketing PV.
Services
IPHARMA conducts pre-clinical studies, develops and manufactures FDFs on the basis of a ChemRar hi-tech laboratory. Having a 25-year experience in the international drug development market, ChemRar conducts pre-clinical studies in compliance with all international requirements and guidelines.
Types of research
1. High Throughput Screening
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Ion channels, GPCR, kinases, HDACs, viral polymerase and protease, etc.
2. In vitro metabolism
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Stability (microsomes and hepatocytes of mouses, rats, dogs, monkeys and humans)
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Permeability (PAMPA test, Caco-2 cell line)
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Solubility, lipophilicity, plasma protein binding
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Interaction with the human cytochrome P450
3. In vivo metabolism
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Pharmacokinetics (LC / MS / MS high sensitivity)
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Bioavailability, biodistribution
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Study of Bioavailability and Bioequivalence
4. Pharmacology. Study of the pharmacological activity
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CNS model, Parkinsonism
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Obesity, violation of food and water consumption, type I diabetes
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Anti-inflammatory and analgesic activity
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Xenografts of human tumors
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Antiviral activity (hepatitis C, influenza)
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5. Toxicology. The study of acute and chronic toxicity
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Study of the general toxicity of substances (acute, sub-chronic, chronic)
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Specific (allergenicity, immunotoxicity, reproductive toxicity)
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Various species (SPF and non-SPF mice, rats, rabbits, minipigi)
Organization of pre-clinical studies
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Clinical laboratory selection
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Development of the protocol and other study documents
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Safety monitoring
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Quality assurance
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Reports preparation