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Therapeutic areas

iPharma conducts phase I – IV clinical trials in various therapeutic areas in compliance with our clients’ requirements.

We conduct studies in the following areas of medicine:

Internal medicine

endocrinology, pulmonology, cardiology, autoimmune diseases, gastroenterology etc.

Oncology

solid tumors, oncohematology, autologous vaccines

Viral infections

Hepatitis B and C, HIV and others

CNS

psychiatric illnesses, neurology

Surgery

cardio surgery, orthopedy, transplantology etc

Preclinical trials

iPharma conducts pre-clinical trials as well as FDF development and production on the base of the IICD high-technological laboratory. IICD has over 25 years of experience of work in the international market on the highest level with the compliance of all requirements and rules of international practice.

High-efficiency panel screening

  • Ion channels, GPCR, kinases, HDACs, virus proteases and polymerases etc

In vitro metabolism

  • Stability (microsomes and hepatocytes in mice, rats, dogs, monkeys and humans)
  • Permeability (PAMPA test, Caco-2 cell line)
  • Solubility, lipophilicity, plasma protein binding
  • Interaction with human cytochromes P450

In vivo metabolism

  • Pharmacokinetics (LC/MS/ high sensitivity MS)
  • Bioavailability, biodistribution
  • Bioequivalence and bioavailability trials
  • Various types of animals (mice, rats, rabbits, dogs, monkeys)

Pharmacology. The study of pharmacological activity

  • CNS models, Parkinsonism
  • Obesity, interrupted food and water consumption, type I diabetes
  • Anti-inflammatory and analgesic activity
  • Human tumor xenografts
  • Antiviral activity (Hepatitis C, influenza)

Toxicology. The study of acute and chronic toxicity

  • The study of overall substance toxicity (acute, subchronic, chronic)
  • Specific (allerginicity, immunotoxicity, reproductive toxicity)
  • Various types of animals (SPF and non-SPF mice, rats, rabbits and minipigs)
  • Pre-clinical trial organization services

· selection of the trial laboratory
· development of the protocol and other study documentation
· safety monitoring
· study conduct quality control
· report preparation